Once all factors have been determined and calibrated, what should result is a couple that interests you and the answer to the question: Why can they not be together and happy/safe/committed?
The story that you write will answer the question: How can they get together and be happy/safe/committed? As you come up against each obstacle to this question and solve it, you will strip away the conflict until by the end of the story, the couple is together and has no outstanding conflict against themselves as individuals and as a couple.
Note: The first two may or may not result in conflict (if both people expect/accept it, it is not a conflict, though it will help shape it), and thus would require something from the third factor to create a story.